A research-informed probiotic and enzyme formulation designed to support gastrointestinal balance, nutrient absorption, and gut–brain axis function during menopause. Provides clinically studied probiotic strains and digestive enzymes to support microbiome integrity and digestive efficiency beyond endogenous and dietary capacity.*

All batch testing and Certificates of Analysis are available in the Menopause Science Trust Center.

Clinical Profile

Targets

• Digestive regularity and comfort*

• Gut microbiome balance*

• Nutrient absorption efficiency*

• Gut–brain axis support for focus and emotional balance*

Primary Actives

Probiotics + Digestive Enzymes
A combination of clinically studied probiotic strains and digestive enzymes that support healthy gut flora, digestive breakdown, and intestinal balance. Supplementation provides functional support when hormonal changes during menopause disrupt normal gastrointestinal processes.*

Formulation Rationale

Hormonal fluctuations during menopause can negatively impact gut motility, microbial balance, and digestive enzyme activity. Endogenous digestive capacity and diet alone may be insufficient to maintain optimal gastrointestinal function during this transition.

This formulation delivers targeted probiotics and enzymes to support digestive regularity, nutrient utilization, and microbiome stability. By supporting gut health, the formula also addresses the gut–brain axis, which plays a role in mood, focus, and emotional well-being.*

Key Characteristics

• Clinically studied probiotic strains and digestive enzymes

• Supports digestive balance and microbiome health during menopause*

• Multi-pathway support for gut and gut–brain axis function*

• Vegetarian capsules

• Non-GMO, gluten-free

• Free from artificial colors, flavors, or preservatives

• Manufactured in an FDA-registered, GMP-certified facility

Full Ingredient List

• Clinically studied probiotic strains

• Digestive enzymes

• Vegetarian capsule

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Trust Center Verified

Comprehensive analysis of clinical research and evidence*

Biome Rebalance Formula By Menopause Science

Gut health isn’t optional. When your digestion is off, everything from bloating to energy and focus can feel harder. Biome Rebalance combines Birch Chaga and Pine Bark extract containing fulvic and humic acids—compounds that may help support healthy gut microbiome balance and digestive function. *

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Research Summary

During menopause and perimenopause, changes in hormone levels can disrupt gut bacteria diversity, slow digestion, and impact nutrient absorption. Research suggests that fulvic acid may help modulate gut microbiota composition by promoting the growth of beneficial bacteria while supporting the intestinal barrier. Pine bark extract provides polyphenols that may further support digestive wellness and antioxidant activity. While limited menopause-specific gut health trials exist, studies in women and mixed populations suggest these compounds may help support digestive comfort, microbiome balance, and overall gastrointestinal wellness.*

Research at a Glance

Plain Language Summary

Hormonal changes during perimenopause and menopause can affect digestion. Many women report bloating, changes in bowel habits, and general digestive discomfort. While research is still emerging, supporting gut health is considered an important part of overall midlife wellness.*

How Gut Health Connects to Hormones
The gut microbiome plays a role in hormone metabolism and mood regulation. Ingredients such as fulvic acid have been studied for their ability to support beneficial bacteria, which may help maintain balance during hormonal transitions.*

Nutrient Absorption as the Body Changes
As metabolism shifts with age, efficient absorption of vitamins and minerals becomes increasingly important for energy, bone health, and overall vitality. Early research suggests fulvic acid may support digestive enzymes and nutrient uptake.*

Antioxidant Support for Comfort
Pine bark extract provides polyphenols, plant-based compounds that offer antioxidant support. This may help maintain a comfortable digestive environment, especially during times of hormonal stress.*

Traditional Wellness Ingredients
Chaga mushroom has a long history of traditional use for general wellness, including digestive health support.*

Key Citations

Primary Research on Fulvic Acid:

1. Gandy JJ, et al. Therapeutic potential of fulvic acid in chronic inflammatory diseases and diabetes. PMC. 2018. PMC: 6151376

Pine Bark Extract Research:

1. Pycnogenol® French maritime pine bark extract in randomized, double-blind, placebo-controlled human clinical studies. Front Nutr. 2024. PMC: 11096518

2. Effect of pine bark extract and its phenolic compounds on selected pathogenic and probiotic bacterial strains. Front Nutr. 2024. Frontiers

Mushroom Gut Health Research:

1. Jayachandran M, et al. A critical review on health-promoting benefits of edible mushrooms through gut microbiota. Int J Mol Sci. 2017. PMC: 5618583

End the Soap Opera in Your Gut

Targeted support to quiet the drama and keep things moving smoothly.

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Important Disclaimer

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Always consult with your healthcare provider before starting any new supplement regimen, especially if you have pre-existing health conditions or are taking medications.

The research cited represents studies conducted on individual ingredients and may not reflect the specific formulation of this product. Individual results may vary based on sleep hygiene, stress levels, health status, and other factors. The research cited represents potential benefits and does not guarantee specific outcomes for all users.